As the first book dedicated to cy-di-GMP, this volume serves as a comprehensive reference on the state of the science for both experienced researchers and those who are interested in discovering its many promising applications. The book examines c-di-GMP from a variety of perspectives and includes chapters covering the comparison of c-di-GMP to cAMP, the role of c-di-GMP, in flagellar biogenesis and motility, extracellular polysaccharide biosynthesis, biofilm development, virulence, and innate host immunity.This new volume of thirty chapters together the latest findings on chemical communication among bacteria and points towards potential areas for future research. Organized into four sections, this volume addresses: cell-cell signaling during development and DNA exchange; signaling in relationship to humans, animals, and plants; production and detection of chemical signals; and eukaryotic quorum sensing.While this book summarizes the major findings in the field, it stimulates cross-fertilization between the piezophile and the nonpiezophile high-pressure research fields. This goal is reflected in the book's organization and content. With eighteen chapters, the book covers a range of issues related to high-pressure microbiology with a firm emphasis on microbial physiology.The twenty-eight chapters contained within this volume are written by experts around the globe to identify extremophiles, explore their unique ecologies, explain their physiologies, and discuss biotechnological applications. This extensive survey is the first to the thoroughly describe the environments where these organisms reside and sheds light, at the molecular level, on the mechanisms that enable these unique organisms to survive.