This book provides an account of the disastrous story of a whole field of research which went astray in different directions, in attempts to solve a problem by using the wrong tools aimed at the wrong target.It all started from the misinterpretation of Schellman's experiments which were carried out in the mid-1950s, and which were later encapsulated by the so-called "Hydrogen-bond inventory argument." This has led Kauzmann to propose the hydrophobic effect, while dismissing the more important hydrophilic effects, in proteins.In addition, as a result of the misinterpretation of Anfinsen's hypothesis, as well as a misunderstanding of the Second Law, people attempted a futile search for the structure of proteins in the global minimum of either the Energy, or the Gibbs Energy Landscape.
Myths and Verities in Protein Folding Theories
- 作者： Ben-Naim, Arieh
- 出版日期： 2016-03-15
- ISBN碼： 9789814725996
- 編號： 203c602253636
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$1,714