Descartes laid the foundation for 17th-century continental rationalism, later advocated by Spinoza and Leibniz, and was later opposed by the empiricist school of thought consisting of Hobbes, Locke, Berkeley, and Hume. Leibniz, Spinoza, and Descartes were all well-versed in mathematics as well as philosophy, and Descartes and Leibniz contributed greatly to science as well. Descartes' Meditations on First Philosophy (1641) continues to be a standard text at most university philosophy departments. Descartes' influence in mathematics is equally apparent; the Cartesian coordinate system was named after him. He is credited as the father of analytical geometry, the bridge between algebra and geometry—used in the discovery of infinitesimal calculus and analysis. Descartes was also one of the key figures in the Scientific Revolution.

The Rene Descartes Collection brings together the finest writings of one of the greatest thinkers of western civilization. The contributions of Descartes played a key role in liberating the western mind from the strangelhold of religion.